diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7dd8f6dd..91d23a38 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -55,6 +55,8 @@ And please only add new entries to the top of this list, right below the `# Unre
 - On Web, the canvas output bitmap size is no longer adjusted.
 - On Web: fix `Window::request_redraw` not waking the event loop when called from outside the loop.
 - On Web: fix position of touch events to be relative to the canvas.
+- On Web, fix `Window:::set_fullscreen` doing nothing when called outside the event loop but during
+  a transient activation.
 
 # 0.28.6
 
diff --git a/Cargo.toml b/Cargo.toml
index bd36953f..8f66bd06 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -156,8 +156,10 @@ features = [
     'WheelEvent'
 ]
 
-[target.'cfg(target_family = "wasm")'.dependencies.wasm-bindgen]
-version = "0.2.45"
+[target.'cfg(target_family = "wasm")'.dependencies]
+js-sys = "0.3"
+wasm-bindgen = "0.2.45"
+wasm-bindgen-futures = "0.4"
 
 [target.'cfg(target_family = "wasm")'.dev-dependencies]
 console_log = "0.2"
diff --git a/src/platform_impl/web/web_sys/canvas.rs b/src/platform_impl/web/web_sys/canvas.rs
index 89a2935a..513561fc 100644
--- a/src/platform_impl/web/web_sys/canvas.rs
+++ b/src/platform_impl/web/web_sys/canvas.rs
@@ -10,8 +10,11 @@ use crate::platform_impl::{OsError, PlatformSpecificWindowBuilderAttributes};
 use std::cell::RefCell;
 use std::rc::Rc;
 
+use js_sys::Promise;
 use smol_str::SmolStr;
-use wasm_bindgen::{closure::Closure, JsCast};
+use wasm_bindgen::prelude::wasm_bindgen;
+use wasm_bindgen::{closure::Closure, JsCast, JsValue};
+use wasm_bindgen_futures::JsFuture;
 use web_sys::{
     AddEventListenerOptions, Event, FocusEvent, HtmlCanvasElement, KeyboardEvent,
     MediaQueryListEvent, MouseEvent, WheelEvent,
@@ -439,7 +442,30 @@ impl Common {
     }
 
     pub fn request_fullscreen(&self) {
-        *self.wants_fullscreen.borrow_mut() = true;
+        #[wasm_bindgen]
+        extern "C" {
+            type ElementExt;
+
+            #[wasm_bindgen(catch, method, js_name = requestFullscreen)]
+            fn request_fullscreen(this: &ElementExt) -> Result<JsValue, JsValue>;
+        }
+
+        let raw: &ElementExt = self.raw.unchecked_ref();
+
+        // This should return a `Promise`, but Safari v<16.4 is not up-to-date with the spec.
+        match raw.request_fullscreen() {
+            Ok(value) if !value.is_undefined() => {
+                let promise: Promise = value.unchecked_into();
+                let wants_fullscreen = self.wants_fullscreen.clone();
+                wasm_bindgen_futures::spawn_local(async move {
+                    if JsFuture::from(promise).await.is_err() {
+                        *wants_fullscreen.borrow_mut() = true
+                    }
+                });
+            }
+            // We are on Safari v<16.4, let's try again on the next transient activation.
+            _ => *self.wants_fullscreen.borrow_mut() = true,
+        }
     }
 
     pub fn is_fullscreen(&self) -> bool {
diff --git a/src/window.rs b/src/window.rs
index f7694bae..a3e49654 100644
--- a/src/window.rs
+++ b/src/window.rs
@@ -941,6 +941,10 @@ impl Window {
     /// - **Wayland:** Does not support exclusive fullscreen mode and will no-op a request.
     /// - **Windows:** Screen saver is disabled in fullscreen mode.
     /// - **Android / Orbital:** Unsupported.
+    /// - **Web:** Does nothing without a [transient activation], but queues the request
+    ///   for the next activation.
+    ///
+    /// [transient activation]: https://developer.mozilla.org/en-US/docs/Glossary/Transient_activation
     #[inline]
     pub fn set_fullscreen(&self, fullscreen: Option<Fullscreen>) {
         self.window.set_fullscreen(fullscreen.map(|f| f.into()))